Download e-book for iPad: Analysis of Complex Diseases: A Mathematical Perspective by Guanyu Wang PhD

By Guanyu Wang PhD

ISBN-10: 1466572213

ISBN-13: 9781466572218

ISBN-10: 146657223X

ISBN-13: 9781466572232

A complicated illness includes many etiological and hazard elements working at a number of levels―molecular, mobile, organismal, and environmental. The prevalence of such illnesses as melanoma, weight problems, and diabetes are expanding in prevalence, urging us to imagine essentially and use a broader point of view to spot their connection and revolutionize remedies. the knowledge of organic facts derived from learning illnesses might be better through theories and mathematical types, which make clear the large photograph and support to bare the overarching mechanisms that govern complicated organic phenomena.

Focusing on ailments relating to mobile power metabolism, equivalent to melanoma and diabetes, Analysis of complicated ailments: A Mathematical Perspective offers a holistic procedure for illuminating the molecular mechanisms of those ailments and the evolutionary underpinning in their simultaneous epidemics. utilizing arithmetic to spot styles of deviation from normality, or the fit state―spanning a number of degrees from molecules to the organism―the writer identifies quite a number dynamical behaviors that correspond to both mobile body structure or pathology. He makes use of the knowledge from a number of degrees in an effort to boost a unified concept, consisting of the invention that yes illnesses may well stem from well-evolved, worthwhile mechanisms activated within the improper context.

This booklet is split into 3 elements. half I specializes in the organismal point to explain common body structure and the way the physique as an entire meets its practical requisites. half II addresses the subcellular, molecular point to explain the organizing rules of mobile biomolecules to satisfy the calls for of the organism. half III examines complicated illnesses by way of combining details from the organismal point and the molecular point, providing a paradigm that may be prolonged to the learn of alternative different types of ailments.

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Extra resources for Analysis of Complex Diseases: A Mathematical Perspective

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Fortunately, muscles can act as a bulk carbon source during starvation, because the low insulin level allows for P1: Naresh Chandra September 30, 2013 24 10:48 K14664 K16584˙C001 Analysis of Complex Diseases: A Mathematical Perspective a rapid degradation of muscle proteins. Amino acids released from muscles can then be used by the liver as the substrate for gluconeogenesis. The conversion of amino acids into pyruvic acids and glucose depends on several enzymes, whose production is stimulated by glucagon and cortisol (an adrenal hormone).

It only stores high-energy electrons in NADH and FADH2 , which have a high potential of P1: Naresh Chandra September 30, 2013 20 10:48 K14664 K16584˙C001 Analysis of Complex Diseases: A Mathematical Perspective transferring the electrons to O2 . To reach O2 , the electrons must flow through a chain of three large protein complexes located in the mitochondrial inner membrane: NADHQ oxidoreductase (Complex I), Q-cytochrome c oxidoreductase (Complex III), and cytochrome c oxidase (Complex IV). These large transmembrane complexes contain multiple oxidation–reduction centers, including quinones, flavins, iron-sulfur clusters, hemes, and copper ions.

The dash-dotted line indicates the fasting glucose concentration. glucose transportation is concerned, the enzyme is GLUT, the substrate is glucose (at the loading site of the plasma membrane), and the product is also glucose (at the releasing site of the plasma membrane). Because we are primarily concerned with the transportation of glucose into a cell, the loading site usually refers to the blood and the releasing site usually refers to the cytoplasm. The reverse transportation is also common.

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Analysis of Complex Diseases: A Mathematical Perspective by Guanyu Wang PhD

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